Ghost Ranch

Quantitative Modeling in Biology

Applications are now closed.

Free workshop: 1-6 June 2025
Ghost Ranch Retreat and Education Center, Abiquiu, New Mexico, USA
Motivation and Topics

Biologists from all subdisciplines are called upon to provide explanations of natural phenomena based upon a thorough understanding of the mechanisms that drive them. As expectations for accuracy in these explanations increase, quantitative models are emerging as useful tools to meet these needs. Of particular use are data-driven inferential models that seek to quantify parameters describing biological mechanisms. However, applications of inferential models across biological disciplines are uneven, and many biologists lack the foundational training necessary to apply them to their research or interpret their results. We maintain that all biologists are capable of sophisticated quantitative modeling in their work, and the primary goal of this workshop is to expand the understanding and use of data-driven modeling among practicing biologists.

The workshop will focus on several learning objectives: (i) to better appreciate the importance of models in biology, (ii) to recognize inference gaps in commonly used models, (iii) to understand the building blocks, the construction, and the analysis of data driven inferential models, and (iv) to communicate clearly about and critically evaluate models developed independently or encountered elsewhere.

Broadly, the workshop will be organized around the following topics:

  • Why model at all? Taming uncertainty for stronger inferences
  • Answering the questions biologists want answered: why is that so hard?
  • Building blocks of inferential models: probability distributions
  • Combining building blocks into models: graphical models
  • Quantitative meaning of graphical models
  • Solving the (almost) impossible: data-driven inferences
  • Should you believe your inference? Quality assurance
  • Where can I apply this new knowledge? Recognizing modeling opportunities

Workshop Location

This five-day workshop will be held at the beautiful and remote Ghost Ranch Retreat and Education Center on the edge of Santa Fe National Forest in northern New Mexico. The location is well-known as the one-time home and frequent artistic subject of the painter Georgia O’Keeffe. All meals and lodging will be provided at the Education Center. We will have plenty of time to focus on quantitative modeling, and also ample opportunities to explore the desert landscape that inspired some of Georgia O’Keefe’s most famous work.

Participant Expectations

We encourage a diversity of participants, including practicing scientists at all levels (especially graduate students, postdoctoral researchers, and early career scientists) as well as managers and policymakers (e.g., agency biologists charged with resource management). Although our own research expertise focuses on population and community biology, we seek a broad representation of biological disciplines, as we have found in our own work that quantitative modeling is applicable to diverse systems across the field of biology.

We do not expect students to have prior experience in statistical modeling or coding. In-class activities will rely primarily on R statistical software, and an introduction to the software will be provided over Zoom the week before the workshop.

Those participants meeting the following expectations will benefit most and will be prioritized if space in the workshop is limited:

  • Having a basic curiosity regarding how inferential modeling could help improve one’s own work and being open to exploring new approaches to modeling, even if they differ from one’s own experience and expertise.
  • Having at least a passing foundation in basic statistics. We recognize that some participants may have last been immersed in this long ago and others may not yet have solidified their understanding. Consequently, we will remind everyone of this as needed, but some background would be helpful.
  • Having at least a passing foundation in basic algebra. It is hard to think about quantitative modeling without some foundation in mathematics.
  • Ideally, participants will be focused on some scientific problem that needs solving and to which data-driven inferential modeling will apply. We hope to help participants formulate at least preliminary modeling ideas to work with after the workshop.

Application–due by Feb 20, 2025 at 3 pm EST

Travel, lodging, and meals will be provided for workshop participants through OSyM. To attend the workshop, please fill out the application form. In the case of over-enrollment, we will select participants based on their interests and backgrounds, so please give thought to your responses.

Organismal Systems Modeling Workshop Application Deadline Extended

The deadline for applications has been extended!

We are excited to announce the first cross training workshop for the Organismal Systems Modeling Workshop
Stability vs. Change: Identifying the Key Questions in Animal Physiology
March 15 to 19, 2020.
Hopkins Marine Station in beautiful Monterey, California

Review of applications will begin Jan 17 2020.
Priority will be given to Postdocs, advanced PhD students and early career Assistant Professors.

 

To submit an application please click here

Organismal Systems Modeling RCN First Cross Training Workshop

We are excited to announce the first cross training workshop for the Organismal Systems Modeling Workshop
Stability vs. Change: Identifying the Key Questions in Animal Physiology
March 15 to 19, 2020.
Hopkins Marine Station in beautiful Monterey, California

Review of applications will begin Jan 17 2020.
Priority will be given to Postdocs, advanced PhD students and early career Assistant Professors.

 

For more information and to submit an application please click here.

OSyM Website Launch

Welcome to our new OSyM website! Explore these pages for information about the RCN and its goals, as well as opportunities for RNC participants to connect, collaborate, participate in workshops, symposia, and research exchanges.

Join OSyM to post your profile and research interests so that potential collaborators in organismal biology, engineering and modeling can connect with you.

Visit the Members page to view the OSyM founding members.

Join our mailing list to receive information about opportunities, events, and meetings.

Join today today!

Introducing OSyM Leadership

Principal Investigators

Dr. Dianna Padilla, Ecology and Evolution, Stony Brook University, (phenotypic plasticity)

Dr. Kendra Greenlee, Biology, North Dakota State University (physiology)

Dr. Dianna Padilla (PI), Ecology and Evolution, Stony Brook University, (phenotypic plasticity), and Dr. Kendra Greenlee (CoPI), Biology, North Dakota State University (physiology) are the leaders of the OSyM RCN. Padilla was the PI of the workshops that lead to this RCN, and she and Greenlee worked hard on several efforts to finally get this RCN funded.

Steering Committee

The Steering Committee plays an important role in keeping the RCN on track and providing input from scientists with a range of expertise. They will be playing a vital role in guiding training opportunities and determining priorities for research exchanges and funding of symposia for the RCN.

Dr. Patsy Dickinson, Biology, Bowdoin College (neurophysiology)

Dr. Daniel Grünbaum, Biological Oceanography, University of Washington (applied mathematics, engineering, modelling)

Dr. Mimi A.R. Koehl, Graduate School, University of California Berkeley (biomechanics, mathematical biology)

Dr. H. Frederik Nijhout, Biology, Duke University (developmental biology and evolution)

OSyM brown bag lunch at the annual meeting of the Society for Integrative and Comparative Biology (SICB)

At the annual meeting of the Society for Integrative and Comparative Biology (SICB) in Tampa Florida in January there was a brown bag lunch meeting to introduce the community of organismal biologists to the new OSyM RCN. This was a question and answer session to inform the community about the goals of this new RCN and the opportunities it will provide for organismal biologists, engineers and modelers to build collaborations as well as obtain advanced training through workshops and research exchanges.

The OSyM steering committee is planning on having a presence at annual SICB meetings for the next several years. They are also looking for additional meetings, particularly meetings frequented by applied mathematicians, modelers and engineers who have interest in working with organismal biologists to take systems-level approaches to answer important biological questions. So, if you have suggestions, please let the steering committee know! Similarly, if you know of upcoming meetings that would be of interest to the community, please let the steering committee know so that such events can be posted on our website.

Welcome to OSyM

The goal of this RCN is to provide avenues for organismal biologists and modeling experts to develop necessary collaborations to improve our predictive ability to understand organismal structure and function.  This RCN is also designed to provide researchers with the training needed to pursue new and exciting ways to explore cutting-edge questions in this emerging, but vital area of research on how animals balance maintaining stability while accommodating change.

OSyM will stimulate and support collaborations through several different mechanisms. It will support the develop perspectives papers on the benefits of these new integrative and quantitative models.  It will also provide support for symposia at national and international meetings of biologists, mathematicians and engineers. It will also create training opportunities that will allow biologists, mathematicians, modelers, and engineers at all levels to gain practical skills in applying them through training workshops as well as through research exchanges.

OSyM is committed to fostering diversity at all levels.  Developing a broad and diverse set of interdisciplinary collaborators is critical for the success of OSyM and for solving Grand Challenge questions in organismal biology. We encourage scientists, engineers and and modeling experts at all career levels and all types of institutions to join this network.

Learn more About OSyM.

Organismal Systems Modeling (OSyM) Research Coordination Network receives funding from NSF

We received notification from NSF that the OSyM Research Coordination Network was provided funding of $500,000 for five years.  The idea for this RCN emerged from a series of workshops designed to develop a research program to address Grand Challenge Questions in Organismal Biology, particularly how organisms walk the tightrope between stability and change.  A goal of this RCN is to facilitate the building of collaborations among organismal biologists, engineers of various types, and modelers to use systems-type models to address questions across a wide range of areas of organismal biology.  Anyone with an interest in this RCN is welcome!